Large-scale Advanced Prop-fan (LAP) technology assessment report

The technologically significant findings and accomplishments of the Large Scale Advanced Prop-Fan (LAP) program in the areas of aerodynamics, aeroelasticity, acoustics and materials and fabrication are described. The extent to which the program goals related to these disciplines were achieved is discussed, and recommendations for additional research are presented. The LAP program consisted of the design, manufacture and testing of a near full-scale Prop-Fan or advanced turboprop capable of operating efficiently at speeds to Mach .8. An aeroelastically scaled model of the LAP was also designed and fabricated. The goal of the program was to acquire data on Prop-Fan performance that would indicate the technology readiness of Prop-Fans for practical applications in commercial and military aviation

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor

<p>Abstract</p> <p>Background</p> <p>Farnesyltransferase inhibitors (FTI) are small molecule agents originally formulated to inhibit the oncogenic functions of Ras. Although subsequent analysis of FTI activity revealed wider effects on other pathways, the drug has been demonstrated to reduce Ras signaling by direct measurements. The purpose of the current study was to determine if FTI could be used to inhibit the inflammatory activities of a known Ras-activating human oncoprotein, RET/PTC3. RET/PTC3 is a fusion oncoprotein expressed in the thyroid epithelium of patients afflicted with thyroid autoimmune disease and/or differentiated thyroid carcinoma. Previous studies have demonstrated that RET/PTC3 signals through Ras and can provoke nuclear translocation of NFκB and the downstream release of pro-inflammatory mediators from thyroid follicular cells <it>in vitro </it>and <it>in vivo</it>, making it an ideal target for studies using FTI.</p> <p>Methods</p> <p>For the studies described here, an <it>in vitro </it>assay was developed to measure FTI inhibition of RET/PTC3 pro-inflammatory effects. Rat thyrocytes transfected with RET/PTC3 or vector control cDNA were co-cultured with FTI and examined for inhibition of chemokine expression and secretion measured by RT-PCR and ELISA. Immunoblot analysis was used to confirm the level at which FTI acts on RET/PTC3-expressing cells, and Annexin V/PI staining of cells was used to assess cell death in RET/PTC3-expressing cells co-cultured with FTI.</p> <p>Results</p> <p>These analyses revealed significant mRNA and protein inhibition of chemokines <it>Ccl2 </it>and <it>Cxcl1 </it>with nanomolar doses of FTI. Neither RET/PTC3 protein expression nor apoptosis were affected at any dose of FTI investigated.</p> <p>Conclusion</p> <p>These data suggest that FTI may be applied as an effective inhibitor for RET/PTC3-oncogene induced pro-inflammatory mediators.</p

The Ursinus Weekly, April 22, 1957

Inter-fraternity weekend is scheduled for April 26 & 27 • Circulate petitions for class officers; Beginning April 22 • Students petition for rule change • Soph rules subject of MSGA meeting • Meistersingers annual tour begins April 28 • Ursinus Woman\u27s Club to hold buffet lunch, May 11 • Spirit Committee elect officers; Martin president • Final total given for Campus Chest; Goal exceeded • Senate studies revised hours for women students • WSGA, WAA, YM-YWCA elections held on April 16: King, Bennignus new Y presidents; Jewett, Justice WSGA, WAA heads • UC debaters vs. Villanova in third 1957 TV debate • Delta Pi Sigma election; Easter party with Sig Nu • SWC sees slides on Europe • Editorial: After the elections, what? • Impressions on an intellectual beggar • Royal humorist grants interview • Twenty-three empty minutes • This matter of rules • Play review: Submerged and Rehearsal • Bears beat Johns Hopkins, Albright in two thrillers • Sabrina Fair, a comedy: Final weeks of rehearsal • KDK has pizza party • Book additions recently received by Library • Pre-medders election; To hear talk by Dr. Subin • UC Summer school session slated for July 8 - Aug. 30https://digitalcommons.ursinus.edu/weekly/1427/thumbnail.jp

Artificial Intelligence Approach to the Determination of Physical Properties of Eclipsing Binaries. I. The EBAI Project

Achieving maximum scientific results from the overwhelming volume of astronomical data to be acquired over the next few decades will demand novel, fully automatic methods of data analysis. Artificial intelligence approaches hold great promise in contributing to this goal. Here we apply neural network learning technology to the specific domain of eclipsing binary (EB) stars, of which only some hundreds have been rigorously analyzed, but whose numbers will reach millions in a decade. Well-analyzed EBs are a prime source of astrophysical information whose growth rate is at present limited by the need for human interaction with each EB data-set, principally in determining a starting solution for subsequent rigorous analysis. We describe the artificial neural network (ANN) approach which is able to surmount this human bottleneck and permit EB-based astrophysical information to keep pace with future data rates. The ANN, following training on a sample of 33,235 model light curves, outputs a set of approximate model parameters (T2/T1, (R1+R2)/a, e sin(omega), e cos(omega), and sin i) for each input light curve data-set. The whole sample is processed in just a few seconds on a single 2GHz CPU. The obtained parameters can then be readily passed to sophisticated modeling engines. We also describe a novel method polyfit for pre-processing observational light curves before inputting their data to the ANN and present the results and analysis of testing the approach on synthetic data and on real data including fifty binaries from the Catalog and Atlas of Eclipsing Binaries (CALEB) database and 2580 light curves from OGLE survey data. [abridged]Comment: 52 pages, accepted to Ap

Development of a custom on-line ultrasonic vapour analyzer/flowmeter for the ATLAS inner detector, with application to gaseous tracking and Cherenkov detectors

Precision sound velocity measurements can simultaneously determine binary gas composition and flow. We have developed an analyzer with custom electronics, currently in use in the ATLAS inner detector, with numerous potential applications. The instrument has demonstrated ~0.3% mixture precision for C3F8/C2F6 mixtures and < 10-4 resolution for N2/C3F8 mixtures. Moderate and high flow versions of the instrument have demonstrated flow resolutions of +/- 2% F.S. for flows up to 250 l.min-1, and +/- 1.9% F.S. for linear flow velocities up to 15 ms-1; the latter flow approaching that expected in the vapour return of the thermosiphon fluorocarbon coolant recirculator being built for the ATLAS silicon tracker.Comment: Paper submitted to TWEPP2012; Topical Workshop on Electronics for Particle Physics, Oxford, UK, September 17-21, 2012. KEYWORDS: Sonar; Saturated fluorocarbons; Flowmetry; Sound velocity, Gas mixture analysis. 8 pages, 7 figure

Affective Temperaments: Unique Constructs or Dimensions of Normal Personality by Another Name?

Abstract: Background

Neurology

Contains reports on six research projects.U. S. Public Health Service (B-3055-4, B-3090-4, MH-06175-02)U. S. Air Force (AF49(638)-1313)U.S. Navy. Office of Naval Research (Nonr-1841(70)